Table 1.
Baseline characteristics.
| Full MDC-CC (n = 6103) | Nested MDC-CC subcohort (n = 583) | Incident MDC-CC HF cases (n = 185) | Manifest HF (n = 84) | Heart transplant recipients (n = 30) | |
|---|---|---|---|---|---|
| Baseline age (years) | 57.48 (5.93) | 56.97 (5.76) | 61.25 (4.76) | 65.79 (12.04) | 51.14 (9.97) |
| Age at diagnosis (years) | 74.75 (6.93) | — | 74.71 (6.93) | — | — |
| Male sex (n [%]) | 2572 (42.14%) | 237 (40.58%) | 106 (56.99%) | 65 (77.38%) | 23 (76.7%) |
| BMI (kg/m2) | 25.77 (3.99) | 25.42 (3.69) | 27.76 (4.49) | 27.66 (6.24) | 26.52 (4.40) |
| SBP (mm Hg) | 141.38 (19.08) | 138.53 (18.11) | 149.31 (19.90) | 123.85 (20.80) | 100.20 (13.56) |
| DBP (mm Hg) | 86.98 (9.46) | 85.52 (9.00) | 89.96 (9.47) | 74.90 (11.95) | 71.55 (9.96) |
| Antihypertensive treatment (n [%]) | 1115 (18.27%) | 86 (14.73%) | 77 (41.40%) | — | — |
| LDL cholesterol (mmol/L) | 4.16 (0.99) | 4.12 (0.97) | 4.15 (1.01) | — | — |
| History of MI (n [%]) | 102 (1.67%) | 9 (1.54%) | 19 (10.22%) | 15 (17.85%) | 3 (10%) |
| History of MI at diagnosis (n [%]) | 79 (25.16) | — | 43 (23.12%) | — | — |
| History of AF at baseline (n [%]) | 58 (0.95%) | 3 (0.51%) | 9 (4.84%) | 33 (39.29%) | 14 (46.67%) |
| History of AF at diagnosis (n [%]) | 145 (44.34%) | — | 87 (46.77%) | — | — |
| History of diabetes (n [%]) | 547 (8.96%) | 53 (9.08%) | 45 (24.32%) | 12 (14.29%) | 3 (10%) |
| Current smoking (n [%]) | 1,620 (27.99%) | 159 (28.24%) | 49 (28.00%) | 7 (8.33%) | 0 |
| Nt-proBNP (pg/mL) | 61.00 (34.00−112.43) | 60.00 (32.14−100.52) | 98.23 (52.14−212.01) | 1036.00 (474.00−2922.00) | 3,997 (2682.75−4929.75) |
| CRP (mg/L) | 1.15 (1.07-1.32) | 1.14 (1.06-1.28) | 1.25 (1.12-1.62) | — | — |
| Creatinine (μmol/L) | 84.76 (16.31) | 84.41 (13.10) | 86.09 (17.19) | 107.14 (34.42) | 117.07 (47.00) |
Characteristics of participants in each of the five study cohorts: (i) the cardiovascular cohort of the population-based Malmö Diet and Cancer Study (MDC-CC), (ii) a random nested subcohort from the MDC-CC for proteomic analysis without prevalent or incident heart failure (HF), (iii) cases with incident heart failure (HF) and plasma available from the MDC-CC, (iv) manifest HF outpatients from the nurse-led HF management program at Skane University Hospital, and (iv) patients with advanced HF who subsequently underwent heart transplantation at Skane University Hospital. Information on a number of parameters was unavailable in the manifest HF cohorts. Continuous variables are presented as mean and standard deviation or median and interquartile range, and categorical variables as count and proportion BMI body mass index, CRP C-reactive protein, DBP diastolic blood pressure, LDL low-density lipoprotein cholesterol, MI myocardial infarction, Nt-proBNP N-terminal pro-B-type natriuretic peptide, SBP systolic blood pressure