Table 3.
Dynamics of proteins for heart failure development before and 6 months after heart transplantation.
| Protein | Before | After | Change | p value |
|---|---|---|---|---|
| Vascular messengers | ||||
| Nt-proBNP | 88,415 (69,500−105,996) | 22,494 (14,353−41,738) | −75% | <0.001 |
| Matrix remodeling | ||||
| TSP2 | 57,588 (31,334−127,082) | 14,626 (11,767−18,097) | −75% | <0.001 |
| Immune system | ||||
| CXCL13 | 3194 (2477−3866) | 8482 (5180−13,676) | +166% | <0.001 |
| CRP | 102,824 (89,798−124,008) | 50,247 (27,082−101,158) | −51% | 0.01 |
| IL-1R antagonist protein | 5073 (3997−6947) | 4858 (3911−5456) | −4% | 0.13 |
| IL-18 receptor 1 | 12,489 (9524−16,322) | 12,032 (9441−15,388) | −4% | 0.47 |
| Complement system | ||||
| C5a | 14,538 (11,751−17,956) | 13,636 (10,065−19,109) | −6% | 0.99 |
| C9 | 86,201 (79,232−95,702) | 80,443 (70,331−95,042) | −7% | 0.28 |
| Coagulation system | ||||
| Protein C | 1048 (874−1304) | 1874 (1737−2114) | +79% | <0.001 |
| tPA | 416 (363−584) | 475 (325−644) | +14% | 0.38 |
| Intracellular or membrane-bound | ||||
| Gelsolin | 700 (654−800) | 868 (800−950) | +24% | <0.001 |
| Carbonic anhydrase 13 | 1156 (543−1500) | 1485 (877−2219) | +28% | 0.06 |
| Contactin-1 | 262 (224−294) | 198 (180−235) | −24% | <0.001 |
| DUSP3 | 1215 (912−1926) | 1213 (875−2115) | 0% | 0.44 |
| PRKACA | 1874 (1589−2486) | 2888 (2189−3923) | +54% | 0.009 |
| Netrin receptor UNC5D | 4849 (3655−5617) | 5875 (4853−7490) | +21% | <0.001 |
Protein levels before and after transplant values presented as median (25th−75th percentile), based on serial measures from 30 heart transplant recipients. Abundance estimates were compared with the Wilcoxon signed-rank test. Abundance expressed as relative fluorescence units (RFU). Proteins grouped according to functional annotations