Figure 6.

Nephron-specific genetic deletion of GR leads to the mirrored phenotype of CAP2/Tmprss4 mice with disturbed water, electrolyte and acid-base handling following low K⁺ diet. Physiological parameters measured following 2 days under regular K⁺ and 4 days under low K⁺ diet (n = 4–6 per genotype). (A) ∆ body weight (BW) as % of initial BW (g), (B) water intake (ml), (C) urine osmolality, (D) cumulative 24 h urinary Na⁺ excretion (mmol), (E) cumulative 24 h urinary K⁺ excretion (mmol), (F) urinary pH, (G) 24 h urinary calcium excretion (µmol/24 h), and (H) 24 h urinary phosphate excretion (mg/24 h) from control (white circles) and Nr3c1^Pax8/LC1 (black circles) mice. *p < 0.05, **p < 0.01.