Table 1.
Physiological parameters of CAP2/Tmprss4 mice after 4 days under low K+ diet.
| Parameters | K+-deficient diet | ||
|---|---|---|---|
| +/+ | ∆/+ | ∆/∆ | |
| n | 6 | 6 | 6 |
| Body weight (g) | 25.01 ± 3.11 | 22.32 ± 3.58 | 20.72 ± 4.46 |
| Food intake (g) | 2.44 ± 0.14 | 2.38 ± 0.10 | 1.94 ± 0.23 |
| Water intake (ml) | 13.10 ± 1.54 | 9.12 ± 0.62** | 7.94 ± 0.81*** |
| Urine volume (ml) | 6.30 ± 0.63 | 3.69 ± 0.75** | 2.21 ± 0.51*** |
| Urine/water ratio | 0.43 ± 0.05 | 0.41 ± 0.07 | 0.36 ± 0.08 |
| Feces (g) | 0.33 ± 0.03 | 0.35 ± 0.02 | 0.27 ± 0.03 |
| Urinary Na+ (mmol) | 0.30 ± 0.05 | 0.31 ± 0.08 | 0.27 ± 0.06 |
| Urinary K+ (mmol) | 0.03 ± 0.01 | 0.05 ± 0.01 | 0.05 ± 0.01 |
| Cumulative Na+ (mmol) | 1.42 ± 0.16 | 1.13 ± 0.27 | 0.93 ± 0.21 |
| Cumulative K+ (mmol) | 0.14 ± 0.03 | 0.21 ± 0.02 | 0.16 ± 0.02 |
| Urinary calcium (µmol/24 h) | 20.59 ± 4.42 | 12.80 ± 1.72 | 9.44 ± 1.75 |
| Urinary phosphate (mg/24 h) | 2.66 ± 0.38 | 1.77 ± 0.11 | 1.36 ± 0.32 |
| 24 h fecal K+ excretion (µmol) | 10.21 ± 2.73 | 12.27 ± 1.98 | 10.80 ± 2.03 |
| Plasma Na+ (mmol/l) | 158.03 ± 2.80 | 150.51 ± 5.52 | 150.10 ± 1.42 |
| Plasma K+ (mmol/l) | 3.52 ± 0.20 | 3.21 ± 0.20 | 3.82 ± 0.41 |
| Aldosterone (nM) | 0.15 ± 0.06 | 0.24 ± 0.08 | 0.26 ± 0.06 |
| Plasma osmolality (mOsm/kgH2O) | 268.17 ± 8.85 | 261.02 ± 7.68 | 257.20 ± 2.27 |