Fig. 1. Vismodegib induces initial tumor response followed by rapid recurrence.

a, b Medulloblastoma in sagittal hindbrain sections stained for pRB, from representative a P15 M-Smo mice, treated with three daily doses of vehicle or vismodegib, or b P25 M-Smo mice treated for 2 weeks with vismodegib, and quantification of pRB⁺ fraction in the indicated groups. c Kaplan–Meier curve comparing survival of M-Smo mice treated with vismodegib or vehicle. d Schematic showing the timing of luciferase imaging and vismodegib administration. e Luciferase signal driven by Gli-luc at indicated times. e′ Luminescence fold change over the indicated intervals in replicate vismodegib-treated and control mice. Each dot represents the value for a specific replicate animal. Horizontal lines indicate the means, and error bars indicate SEM. p Values determined by two-sided Student’s t-test. Scale bars = 2 mm, except in insets, where scale bars = 50 µm.