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. 2019 Dec 20;10:5829. doi: 10.1038/s41467-019-13657-6

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© The Author(s) 2019, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Correlation plot after imputation of data, showing expression of Gli1 on the X-axis and Ptch1 on the Y-axis, in vehicle- and vismodegib-treated tumors graphed separately. Each dot represents an individual cell. b Correlation plot after imputation of data, showing expression of Sufu on the X-axis and Gli1 on the Y-axis, in vehicle and vismodegib-treated tumors graphed separately as in a. c t-SNE projection of Sox2⁺ cells from vehicle-treated and vismodegib-treated tumors, directed by ICA with expression of Fabp7 and Hes1 color coded. d t-SNE projection of Sox2⁺ cells from the five vehicle-treated and five vismodegib-treated tumors, directed by ICA, with expression of Nes, Vim and Yfp indicated. e Bar plots comparing the proportions of Sox2⁺ cells expressing indicated markers in each of the five vehicle-treated or vismodegib-treated tumors. Error bars are SEM. The Yfp⁺ fractions are indicated.