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. 2019 Dec 20;10:5815. doi: 10.1038/s41467-019-13854-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic diagram shows EMG potentials recorded in contralateral gastrocnemius muscle in response to electrical stimulation in the motor cortex of mice at 6 weeks after a T9 contusion. Representative examples of EMG traces were evoked by motor-cortex stimulation in the sham, SCI + AAV-GFP, and SCI + AAV-NT-3 treatment groups after SCI. The dotted line indicates the onset of EMG response in an AAV-NT-3-treated mouse; the arrows indicate the EMG latency. b Schematic diagram illustrates EMG activity in each group at 1 day after bilateral pyramidotomy. c Schematic diagram shows EMG potentials recorded in the contralateral gastrocnemius muscle in response to electrical stimulation in the red nucleus of mice at 6 weeks after the T9 contusion. Representative examples of EMG traces were plotted for each animal group. d Schematic diagram illustrates the EMG activities in each animal group at 1 day following bilateral lateral hemisection to transect the RST at the C5 vertebral level. e Quantitative analysis of cortico-stimulation-induced EMG amplitudes and latencies of the sham (44 stimulation sites from 6 mice), SCI + AAV-GFP (57 stimulation sites from 8 mice), and SCI + AAV-NT-3 (50 stimulation sites from 7 mice) animal groups. f Quantitative analysis of rubro-stimulation-induced EMG amplitudes and latencies in the sham (44 stimulation sites from 5 mice), SCI + AAV-GFP (49 stimulation sites from 6 mice), and SCI + AAV-NT-3 (45 stimulation sites from 6 mice) animal groups. The black dots represent independent stimulation sites from each group. The yellow lines from violin plots indicate mean ± SD. The dashed lines in histograms indicate the mean line from each group. ***P < 0.001. One-way ANOVA followed by Tukey’s multiple comparison test. EMG electromyography, CST corticospinal tract, RST rubrospinal tract. Source data are provided as a Source Data file.