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. 2019 Dec 20;9:19500. doi: 10.1038/s41598-019-55739-x

Figure 1.

Figure 1

Assessment of mild TBI-induced mechanical hypersensitivity after systemic 5-HT depletion. Once daily systemic  treatment for 4 days with 100 mg/kg p-Chlorophenylalanine (PCPA) in mild TBI mice resulted in recovery of mechanical hypersensitivity in (a) ipsilateral and (b) contralateral hindpaw (relative to injury side). Arrow indicates when the TBI was performed. Data were analyzed by multiple t tests using the Holm-Sidak method to correct for multiple comparisons. *Indicates significant difference in comparison with respective limb measurements in vehicle group. Error bars: SEM, n = 10/group.