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. 2019 Dec 20;9:19500. doi: 10.1038/s41598-019-55739-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of CXCR2 antagonist treatment on mild TBI induced mechanical hypersensitivity. (a) Systemic SCH527123 treatment for 7 days (Day 0 to 6) dose dependently attenuated mechanical hypersensitivity after TBI with the 10 mg/kg dose having the maximal reversal effect. Mechanical hypersensitivity after mild TBI remained attenuated during SCH527123 treatment and was reestablished upon cessation. (b) Intrathecal application of SCH527123 (black arrow) 3 µg on day 3 after mild TBI restored mechanical thresholds to baseline values. Data were analyzed by multiple t tests using the Holm-Sidak method to correct for multiple comparisons. ^*Indicates significant difference in comparison with limb measurements in TBI/vehicle group. Error bars: SEM, n = 6–8/group.