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. 2019 Dec 20;9:19603. doi: 10.1038/s41598-019-56132-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of SB on repeated WAS- or CRF-induced visceral changes. WAS induced visceral allodynia and colonic hyperpermeability, which were reversed by SB (A,B). SB also blocked CRF-induced visceral changes (C,D). Sham, sham stress. *p < 0.05 vs. vehicle + sham or vehicle + vehicle, ^#p < 0.05 vs. vehicle + WAS or vehicle + CRF by two-way ANOVA followed by Tukey’s HSD test. Each column represents mean ± SEM. The number of rats examined is shown in parentheses (n = 5−6).