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. 2019 Dec 20;10:5806. doi: 10.1038/s41467-019-13646-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Each KT column represents an individual xenograft. Clinical characteristics are outlined in the top panel. Children’s Oncology Group (COG) disease stage is indicated. For bilateral WT cases (stage 5) also with metastasis present, the stage is indicated as 5/4. Neoadjuvant indicates that the patient received neoadjuvant chemotherapy before surgical resection and establishment of the WTPDX. SIOP HR path (as per International Society for Pediatric Oncology Classification) indicates high-risk histology (diffuse anaplasia or blastemal predominance) after neoadjuvant chemotherapy. Relapse indicates that the patient later experienced relapse during the clinical course. Genetic variants and chromosomal copy number alterations (CNAs) are displayed in the lower two panels. The type of sequencing performed (WES with target capture sequencing, Sanger sequencing, or both) is shown. Each finding is depicted for the WTPDX—primary tumor pair, with the left rectangle representing presence of the variant or CNA in the WTPDX, and the right rectangle representing an equivalent finding in the parent primary tumor. An unfilled (white) rectangle indicates absence of this finding in either the WTPDX or primary tumor. Specimens for which primary tumor tissue was not available are indicated by black rectangles.