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. 2019 Dec 20;10:5806. doi: 10.1038/s41467-019-13646-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Paired favorable-histology, triphasic primary Wilms tumor (WT) a and WTPDX b corresponding to case KT-45 are shown in the top two rows. WTPDX b maintain the epithelial, stromal, and blastemal triphasic histology of primary WT a. WTPDX maintain blastemal SIX2 expression (middle) and WT1 expression (right) b compared with the primary WT a. Paired unfavorable-histology (diffuse anaplasia) WT c and WTPDX d corresponding to case KT-60. WTPDX d maintain the hyperchromatic, large nuclei, and atypical multipolar mitoses (arrows) of the primary WT c. WTPDX d retain p53 immunostaining that is characteristic of tumors with TP53 missense mutations. Scale bar = 100 μm.