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. 2019 Dec 20;10:5806. doi: 10.1038/s41467-019-13646-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The percentage of blastema is plotted for primary tumors (triangles) versus corresponding early-passage xenografts (circles), demonstrating that most xenografts enrich for the blastemal component by histology. b A significant increase in the percentage of blastema by histology was found when the entire group of primary tumors versus early-passage xenografts were compared. c The percent blastema was compared between nine triphasic primary tumors and the first five passages of corresponding WTPDX (P1-P5). A significant increase in percent blastema was found at the first passage and maintained through passage 5. Error bars in b and c represent mean ± standard deviation. P values are from a paired two-tailed t-test.