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. 2019 Dec 20;10:5817. doi: 10.1038/s41467-019-13805-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Original and replication screens from each institute plotted by their first two principal components. HT-29 screens are highlighted. Axes are scaled to the variance explained by each component. b Correlations of the changes in gene score caused when changing a single experimental condition. c The difference in unprocessed gene scores between Broad screens of HT-29 and the original Sanger screen (Sanger minus Broad), beginning with the Broad’s original screen and ending with the Broad’s screen using the KY library at the 14-day time point. Each point is a gene. The horizontal axis is the mean difference of the gene’s score between the Sanger and Broad original unprocessed data sets. d A similar plot taking the Broad’s original screen as the fixed reference and varying the Sanger experimental conditions (Broad minus Sanger).