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. Author manuscript; available in PMC: 2021 Jan 15.
Published in final edited form as: Biol Psychiatry. 2019 Jul 11;87(2):150–163. doi: 10.1016/j.biopsych.2019.06.029

Figure 4. Characterizing the 22qBD-PPI Network Relative to Genomic-Region and Gene-Set BD-PPI Networks.

Figure 4.

Null distributions for number of BD-PPI network genes per module across all: (A) ~2.57 Mb genomic regions (i.e., 12,149 Genomic-RegionBD-PPI networks) and (B) random 38 seed gene gene-sets (i.e., 10,000 Gene-SetBD-PPI networks), derived to characterize the 22q11.2 locus relative to all regions of the genome, and the connectivity of 22q11.2 genes within brain development protein networks, respectively. Boxplots mark the median number of BD-PPI network genes per module, with lower and upper hinges corresponding to the 25th and 75th quartiles, respectively, and the whiskers extending to 1.5 x interquartile range. The number of 22qBD-PPI network genes in each module are marked in red. *22qBD-PPI network P<0.05 relative to null Genomic-RegionBD-PPI or Gene-SetBD-PPI network distribution.