Skip to main content
. Author manuscript; available in PMC: 2021 Jan 15.
Published in final edited form as: Biol Psychiatry. 2019 Jul 11;87(2):150–163. doi: 10.1016/j.biopsych.2019.06.029

Figure 5. Prioritizing Individual 22q11.2 Genes Based on BD-PPI Network Overlap with Each SCZ- and/or ASD-Associated BrainSpan Module.

Figure 5.

Number of genes in each individual 22q11.2 gene’s BD-PPI network belonging to the: (A) M1, (B) M4, (C) M6, (D) M7, (E) M12, (F) M13, and (G) M15 SCZ- and/or ASD-associated modules. In each plot, 22q11.2 genes are shown grouped by module membership along the x-axis. The top, second, and third red dotted lines in each plot mark the number of BD-PPI network genes nearest to the 99th, 95th, and 75th percentile (when above 0) of all BrainSpan genes for each module. Bar plots are colored by module color. *PGENE NETWORK<0.05 and **PGENE NETWORK<0.01 for each module, relative to the BD-PPI networks of all BrainSpan genes. ^Module enriched for neuronal cell-type markers.