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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Trends Genet. 2019 Nov 18;36(1):30–43. doi: 10.1016/j.tig.2019.10.004

Figure 2: Schematic illustration of cis-asymmetry and trans-asymmetry, which coordinate to ensure nonrandom sister chromatids segregation in Drosophila male GSCs.

Figure 2:

(A) Dynamic interactions between cis and trans factors at different stages during the cell cycle of Drosophila male GSCs. From mid-G2 to G2/M transition, microtubules from the mother centrosome actively interact with and break nuclear envelope locally at the stem cell side in early prophase. Microtubules emanated from the mother centrosome then interact with the centromeres and preferentially attach to the stronger centromere. At a later time point in prometaphase, microtubules from the daughter centrosome break the nuclear envelope at the differentiating daughter cell side and attach to the weaker centromere. (B) Breaking the trans-asymmetry using nocodazole (NZ) disrupts the temporal asymmetry in microtubule activity, which results in the loss of preferential sister chromatid attachment and randomizes their segregation in anaphase. (C) Summary of disrupting mitotic drive which leads to randomized sister chromatid segregation.