Figure 1. Prexasertib plasma pharmacokinetic model and visual predictive checks.

(A) Prexasertib plasma pharmacokinetic model structure: a two-compartment linear model parameterized with apparent central clearance (CL) and volume (V_c), peripheral clearance (Q) and volume (V_p), and an absorption rate constant (k_a) to describe the subcutaneous administration. (B) Prexasertib plasma concentration-time profile in mice bearing G3MB: observations (open-circles) vs model predictions. The solid line represents the median of model predictions, and the shaded area depicts the 90^th prediction interval.