Figure 2. Prexasertib ECF pharmacokinetic model and visual predictive checks.

Prexasertib ECF model structure (A): a two-compartment linear model parameterized with influx and efflux clearances (CL_in and CL_eff), and peripheral rate constants (k_b45 and k_b54). The amount of drug moving from plasma to ECF was multiplied by the fraction unbound F_U. A separate compartment was used to model the microdialysis fractions. Model predictions of prexasertib ECF concentrations in mice bearing G3MB (B) and in non-tumor bearing mice (C). In (B) and (C), the open-circles are the observed ECF concentrations, the crosses are the simulated data below the limit of quantification, the solid line represents the median of model predictions, the shaded area depicts the 90^th prediction interval.