. Author manuscript; available in PMC: 2021 Jan 15.

Published in final edited form as: Eur J Pharm Sci. 2019 Oct 25;142:105106. doi: 10.1016/j.ejps.2019.105106

Table 3.

Parameter estimates for prexasertib plasma pharmacokinetic model

Parameters^†		Units	Estimate (RSE%)	IIV% (RSE%)
k_a	Absorption rate constant	h⁻¹	1.07 (12%)	20.0 (21%)
CL	Plasma (central) clearance	l/h/kg	5.64 (4.3%)	21.5 (23%)
V_c	Plasma (central) volume	l/kg	1.81 (18%)	-
Q	Tissue (peripheral) clearance	l/h/kg	0.58 (13%)	16.3 (23%)
V_p	Tissue (peripheral) volume	l/kg	3.42 (8.0%)	-

RSE% relative standard error, IIV% inter-individual variability reported as coefficient of variation The residual proportional error was fixed to 5%.

^†

Estimated prexasertib clearance and volume were apparent parameters in the absence of data collected after IV in this model.