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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Trends Microbiol. 2019 Oct 6;28(1):46–56. doi: 10.1016/j.tim.2019.08.007

Figure 2. Key host interaction partners of influenza A virus NS1 are highly divergent between relevant host species.

Figure 2

The amino acid identities between pig (Sus scrofa), waterfowl (mallard duck (Anas platyrhynchos) or goose (Anser anser domesticus)), ferret (Mustela putorius furo) and human (Homo sapiens) for PKR, RIG-I (DDX58), TRIM25, RNF135/RIPLET and NOLC1 are shown in colored boxes. For waterfowl, mallard duck proteins were analyzed, except for PKR (goose), because a high-quality mallard PKR sequence is not available. Sequence identities shown were determined from psi-blast searches and are very similar to sequence identities obtained from multiple sequence alignments. Accession numbers for PKR (eIF2aK2): NP_002750.1; NP_999484.1; XP_012918395.1 (first 39 aa missing from sequence); AXJ21467.1. RIG-I (DDX58): NP_055129.2; NP_998969.2; XP_004765417.2; BAO25514.1. TRIM25: NP_005073.2; XP_005657028.3; XP_012909123.1; XP_012948210.2. RNF135 (Riplet): NP_115698.3; XP_003131783.1; XP_004747119.1; XP_027327216.1 (contains a unique 97 aa N-terminal extension, which was excluded from analyses). NOLC1: NP_001271317.1; XP_005671467.1; XP_004749466.1; XP_027316116.1.