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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: SLAS Discov. 2019 Jul 30;25(1):79–86. doi: 10.1177/2472555219860771

Figure 1.

Figure 1.

High-throughput screen for identifying inhibitors of HPV infection. Shown is a schematic illustrating the basic steps in the HTS. See Materials and Methods for additional details. Briefly, HPV16-PsVs containing the Renilla reporter genes are analyzed for their ability to infect as judged by the levels of luminescence. Cell viability was assessed in parallel 384-well plates. In the specific HTS carried out in this study, the compounds were added at a 8.3 μM/0.3% DMSO final concentration 2 h prior to infection.