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Two lead FDA drugs. (A) Pentamidine exhibited more than 100-fold selective inhibition of HPV16-PsV infection (IC50 ≤ 0.002 μM) compared with cell viability (IC50 = 0.08 μM). (B) Securinine exhibited 90-fold selective inhibition of HPV 16-PsV infection (IC50 = 9 μM) compared with cell viability (IC50 = 42.0 μM).
