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. Author manuscript; available in PMC: 2021 Jan 15.
Published in final edited form as: Biol Psychiatry. 2019 Aug 9;87(2):113–122. doi: 10.1016/j.biopsych.2019.07.032

Table 3.

Effect of estrogen on brain volume change at age 10 and age 14.

Age 10 Age 14
Region TS E− v TS E +
T-value (p-value)		 TS E− v TS E +
T-value (p-value)
Less Gray Matter Over Time
Right Calcarine-Lingual 0.019 (p<0.98)
Age Interaction: 2.43 (p<0.17)		 2.81 (p<0.0071)
Age Interaction: 2.43 (p<0.01)
Left Postcentral-Inferior Parietal 0.9 (p<0.3)
Age Interaction: 2.5 (p<0.01)		 3.9 (p<0.0002)
Age Interaction: 2.5 (p<0.01)
Right Postcentral Inferior Parietal 1.1 (p<0.27)
Age Interaction: 2.5 (p<0.01)		 4.1 (p<0.0001)
Age Interaction: 2.5 (p<0.01)
Right Middle Temporal 1.28 (p<0.2)
Age Interaction: 2.0 (p<0.04)		 3.7 (p<0.0005)
Age Interaction: 2.0 (p<0.04)
Increased Gray Matter Over Time
Left Lingual-Cerebellar 0.63 (p<0.52)
Age Interaction: 1.8 (p<0.07)		 2.6 (p<0.0097)
Age Interaction: 1.8 (p<0.07)
Right Parahippocampal 1.79 (p<0.07)
Age Interaction: 1.36 (p<0.17)		 3.6 (p<0.0006)
Age Interaction: 1.36 (p<0.17)
Left Putamen −1.5 (p<0.13)
Age Interaction: 1.14 (p<0.25)		 −0.59 (p<0.55)
Age Interaction: 1.14 (p<0.25)
Right Insula-Superior Temporal −1.5 (p<0.13)
Age Interaction: 2.4 (p<0.1)		 0.8 (p<0.42)
Age Interaction: 2.4 (p<0.01)
Less White Matter Over Time
Left Precentral 0.67 (p<0.54)
Age Interaction: 2.52 (p<0.01)		 3.68 (p<0.0006)
Age Interaction: 2.52 (p<0.01)
Right Supramarginal 0.30 (p<0.76)
Age Interaction: 2.7 (p<0.008)		 3.66 (p<0.0006)
Age Interaction: 2.72 (p<0.008)
Left Calcarine-Lingual −0.08 (p<0.93)
Age Interaction: 2.2 (p<0.02)		 2.58 (p<0.01)
Age Interaction: 2.24 (p<0.02)
Left Cuneus-Precuneus 0.37 (p<0.71)
Age Interaction: 1.69 (p<0.09)		 2.49 (p<0.01)
Age Interaction: 1.69 (p<0.09)
Left Postcentral 0.63 (p<0.52)
Age Interaction: 2.67 (p<0.009)		 0.44 (p<0.65)
Age Interaction: 1.65 (p<0.1)