Table 2.
Cell cytotoxicity and anti-influenza virus activity of pomegranate peel extract and fractions
| Extract/fractions | CC50aμg/ml (CI95%) | IC50bμg/ml (CI95%) | SIc |
|---|---|---|---|
| Crude extract | 55.6 (48.4–64) | 6.4 (4.5–9.2) | 8.63 |
| n-hexane fraction | 238.2 (142.4–398.4) | >238.2 | - |
| Chloroform fraction | 34.1 (30.1–38.6) | >34.1 | - |
| Ethyl acetate fraction | 29.7(24.9–35.3) | 5.6 (3.9–7.9) | 5.3 |
| n-butanol fraction | 55.61 (47.1–65.6) | 6.1 (4.5–8.13) | 9.16 |
| Oseltamivir (μmol)* | 539.4 (378.9–768.5) | 0.87 (0.55–1.4) | 617.8 |
a
CC50: 50% cytotoxic concentration (MDCK cell);
b
IC50: 50% inhibitory concentration (PR8 influenza virus);
c
SI: Selectivity index, i.e., the ratio of CC50 to IC50; CI95%: 95% confidence interval;
*
oseltamivir used as positive control.