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. 2019 Dec 21;10:408. doi: 10.1186/s13287-019-1511-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Melatonin enhances the BMP9 signalling pathway in the regulation of C3H10T1/2 osteogenic differentiation. a, b Melatonin enhances BMP9 expression and the phosphorylation of its downstream protein Smad1/5/8 in C3H10T1/2 cells. c p-Smad1/5/8 is transferred from the cytoplasm to the nucleus