Fig. 4.

SBF-1 ameliorated ear swelling in mice with contact hypersensitivity induced by picryl chloride. Contact hypersensitivity was induced in BALB/c mice by PCl. SBF-1 or vehicle control was administered i.p. daily from day 0. a Body weight changes. b Ear swelling. c–g Ear tissues harvested from vehicle- or SBF-1-treated mice on day 6 were analyzed for degree of inflammation by H&E (original magnification × 200). c The pathological score. Data are mean ± SEM of six animals per group. P values were determined by one-way ANOVA with Tukey’s correction. *P < 0.05, **P < 0.01. d–g Representative photographs of each group: Vehicle d 5 μg/kg SBF-1 e 10 μg/kg SBF-1 f 10 mg/kg cyclosporine A g