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. 2019 Dec 21;8:204. doi: 10.1186/s13756-019-0652-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Results from probabilistic sensitivity analysis for CAZ-AVI sequence vs. Ceftolozane/Tazobactam sequence, on cost-effectiveness plane. Abbreviations: CAZ-AVI, ceftazidime-avibactam; QALY, quality-adjusted life year; WTP, willingness-to-pay

. CAZ-AVI sequence: CAZ-AVI plus metronidazole, followed by colistin + tigecycline + high-dose meropenem.

Ceftolozane/tazobactam sequence: Ceftolozane/tazobactam plus metronidazole, followed by colistin + tigecycline + high-dose meropenem.

Notes: Each dot represents the cost-effectiveness outcome from each iteration. The threshold lines represent cost-effectiveness thresholds of € 30,000 or € 40,000 per QALY (i.e., the maximum amount society is willing to pay for a QALY gained). In cases that fall to the right and below this line, the CAZ-AVI sequence is cost effective compared to the ceftolozane/tazobactam sequence. In cases that fall to left and above this line, the CAZ-AVI sequence is not cost effective compared to the ceftolozane/tazobactam sequence