Table 3.
Distribution of genotype and allele frequencies of VDR variants in controls, cases and patient subgroups
| VDR polymorphisms | Genotype frequency n, (%) |
P* | Allele frequency n, (%) |
P* | Comparisons | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ApaI (rs7975232) | CC | AC | AA | C | A | ||||||||
| Controls | 114 | (48.7) | 106 | (45.3) | 14 | (6) | NS | 334 | (71.4) | 134 | (28.6) | NS | Cases vs. controls |
| Cases | 203 | (47.8) | 183 | (43.2) | 38 | (9) | 589 | (70) | 259 | (30) | |||
| CHB | 76 | (42.2) | 94 | (52.2) | 10 | (5.6) | NS | 246 | (68.3) | 114 | (31.7) | NS | LC vs. CHB |
| LC | 41 | (50.6) | 32 | (39.5) | 8 | (9.9) | NS | 114 | (70.3) | 48 | (29.7) | NS | HCC vs. LC |
| HCC | 86 | (52.8) | 57 | (35) | 20 | (12.3) | 0.0022 | 229 | (70.2) | 97 | (29.8) | NS | HCC vs. CHB |
| non-HCC | 117 | (44.8) | 126 | (48.3) | 18 | (6.9) | 0.013 | 360 | (69) | 162 | (31) | NS | HCC vs. Non-HCC |
| FokI (rs2228570) | GG | GA | AA | G | A | ||||||||
| Controls | 49 | (23) | 116 | (54.5) | 48 | (22.5) | NS | 214 | (50.2) | 212 | (49.8) | NS | Cases vs. controls |
| Cases | 108 | (25) | 233 | (54) | 91 | (21) | 449 | (52) | 415 | (48) | |||
| CHB | 49 | (27.8) | 91 | (51.7) | 36 | (20.5) | NS | 189 | (53.7) | 163 | (46.3) | NS | LC vs. CHB |
| LC | 12 | (15.4) | 47 | (60.3) | 19 | (24.3) | NS | 71 | (45.5) | 85 | (55.5) | NS | HCC vs. LC |
| HCC | 47 | (26.4) | 95 | (53.4) | 36 | (20.2) | NS | 189 | (53) | 167 | (47) | NS | HCC vs. CHB |
| non-HCC | 61 | (24) | 138 | (54.3) | 55 | (21.7) | NS | 260 | (51.2) | 248 | (48.8) | NS | HCC vs. Non-HCC |
| TaqI (rs731236) | TT | TC | CC | T | C | ||||||||
| Controls | 177 | (90.8) | 18 | (9.2) | 0 | (0) | NS | 372 | (95.4) | 18 | (4.6) | NS | Cases vs. controls |
| Cases | 423 | (91.4) | 40 | (8.6) | 0 | (0) | 886 | (95.7) | 40 | (4.3) | |||
| CHB | 168 | (92.3) | 14 | (7.7) | 0 | (0) | NS | 350 | (96.2) | 14 | (3.8) | NS | LC vs. CHB |
| LC | 81 | (91.1) | 8 | (8.9) | 0 | (0) | NS | 170 | (95.5) | 8 | (4.5) | NS | HCC vs. LC |
| HCC | 174 | (90.6) | 18 | (9.4) | 0 | (0) | NS | 366 | (95.4) | 18 | (4.6) | NS | HCC vs. CHB |
| non-HCC | 249 | (91.9) | 22 | (8.1) | 0 | (0) | NS | 520 | (96) | 22 | (4) | NS | HCC vs. Non-HCC |
| BsmI (rs1544410) | CC | CT | TT | C | T | ||||||||
| Controls | 196 | (92.5) | 16 | (7.5) | 0 | (0) | NS | 408 | (96.2) | 16 | (3.8) | NS | Cases vs. controls |
| Cases | 404 | (94) | 26 | (6.0) | 0 | (0) | 838 | (97) | 26 | (3) | |||
| CHB | 162 | (92.6) | 13 | (7.4) | 0 | (0) | NS | 337 | (96.3) | 13 | (3.7) | NS | LC vs. CHB |
| LC | 71 | (93.4) | 5 | (6.6) | 0 | (0) | NS | 147 | (96.7) | 5 | (3.3) | NS | HCC vs. LC |
| HCC | 171 | (95.6) | 8 | (4.4) | 0 | (0) | NS | 350 | (97.7) | 8 | (2.3) | NS | HCC vs. CHB |
| non-HCC | 233 | (92.8) | 18 | (7.2) | 0 | (0) | NS | 484 | (96.4) | 18 | (3.6) | NS | HCC vs. Non-HCC |
CHB chronic hepatitis B, LC liver cirrhosis, HCC hepatocellular carcinoma; Cases = all HBV infected patients; non-HCC, CHB + LC, n = number of chromosomes; OR adjusted Odds Ratio, NS not significant, (*) Chi squared test