Table 4.
Association of ApaI variant with liver disease progression
| ApaI SNP | CHB | CHB + LC (non-HCC) |
HCC | HCC vs. CHB | HCC vs. non-HCC | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | OR (95%CI) | P* | OR (95%CI) | P* | |
| Codominant | ||||||||||
| CC | 76 | 42.2 | 117 | 44.8 | 86 | 52.8 | 1 | Ref | 1 | Ref |
| CA | 94 | 52.2 | 126 | 48.3 | 57 | 35 | 0.5 (0.3–0.84) | 0.004 | 0.6 (0.4–0.98) | 0.04 |
| AA | 10 | 5.6 | 18 | 6.9 | 20 | 12.3 | 1.84 (0.7–4.8) | 0.206 | 1.4 (0.7–3.0) | 0.189 |
| Dominant | ||||||||||
| CC | 76 | 42.2 | 117 | 44.8 | 86 | 52.8 | 1 | Ref | 1 | Ref |
| CA + AA | 104 | 57.8 | 144 | 55.2 | 77 | 47.2 | 0.62 (0.37–0.94) | 0.04 | 0.72 (0.47–1.1) | 0.13 |
| Recessive | ||||||||||
| CC + CA | 170 | 94.4 | 243 | 93.1 | 143 | 87.7 | 1 | Ref | 1 | Ref |
| AA | 10 | 5.6 | 18 | 6.9 | 20 | 12.3 | 2.56 (1.01–6.48) | 0.04 | 1.74 (0.8–3.65) | 0.14 |
| Overdominant | ||||||||||
| CC + AA | 86 | 47.8 | 135 | 51.7 | 106 | 65 | 1 | Ref | 1 | Ref |
| CA | 94 | 52.2 | 126 | 48.3 | 57 | 35 | 0.46 (0.27–0.76) | 0.0023 | 0.6 (0.38–0.90) | 0.017 |
CHB Chronic hepatitis B, LC Liver cirrhosis, HCC Hepatocellular carcinoma; Non-HCC, CHB + LC; n = number of chromosomes; OR adjusted Odd Ratio; ORs and P values were calculated by using binary logistic regression model adjusted for age and gender. (*) Logistic regression model adjusted for age and gender. Bold values present the statistical significance