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. 2019 Dec 21;20:290. doi: 10.1186/s12931-019-1214-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Influence of VX drugs on IκBα stabilization in CF cells. a-d Influence of VX drug monotherapies (a) and combination therapies (b-d) on IκBα stability without and with TNFα treatment (n = 3 biological replicates for all conditions; representative Western blots per experiment are displayed). Abbreviations: C (Control, no additions), D (DMSO, dimethylsufoxide), 661 (VX-661; Tezacaftor®, 3 μM), 770 (VX-770, Ivacaftor® 1 μM), 809 (VX-809, Lumacaftor®, 3 μM), MIX (mixture of VX-661 and VX-770 [B], VX-661 and VX-809 [C], or VX-770 and VX-809 [D])