Table 3.
DMRs identified by both comb-p and DMRcate*
| DMR | CpGs comprising the DMR | Direction of association | Nearby gene(s) | Regulatory feature group/gene group/relation to island |
|---|---|---|---|---|
| comb-p (500 and 1,000 bp window) | ||||
| chr 1: 248100345–248100614 | cg00785941, cg03748376, cg04028570, cg08260406, cg08944170, cg20434529, cg20507276 | − | OR2L13, CLK3P2 | Promoter-associated/first exon: 5′UTR or TSS200/island or north shore |
| chr 10: 135342218–135342413 | cg10862468, cg25330361 | − | CYP2E1 | NA/body/island |
| DMRcate (500 bp window)chr 1: 248100407–248100614 | cg00785941, cg03748376, cg04028570, cg08260406, cg08944170, cg20507276 | − | OR2L13 | Promoter-associated/first exon/5′UTR/island |
| DMRcate (1,000 bp window) | cg00321709, cg10862468, cg19469447, cg23400446, cg24530264, cg25330361 | − | CYP2E1 | Unclassified/body/island |
| chr 10: 135341870–135342620 |
NA, not applicable. UTR, untranslated region.
*
DMRs were identified from meta-analysis results for individual CpGs, which used results from robust linear regression models that were adjusted for newborn sex, maternal age (in years), maternal BMI (prepregnancy or early pregnancy), maternal education, maternal smoking status during pregnancy (ever vs. never), maternal genetic ancestry (if available) or maternal race/ethnicity, and estimated cord blood cell fractions.