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. 2019 Sep 26;43(1):169–177. doi: 10.2337/dc19-0803

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© 2019 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Classical HLA haplotype/alleles association with type 1 diabetes diagnosed at <7 years old (red circle; mean log-odds ratio age at diagnosis ± 95% CI), 7–13 years old (green circle; mean log-odds ratio age at diagnosis 7–13 ± 95% CI), and ≥13 years old (blue circle; mean log-odds ratio age at diagnosis ≥13 ± 95% CI), from a multinomial logistic regression. Left panel shows the log-odds ratios, with a dashed red line showing a log-odds ratio of 0. The right panel shows the association statistics from a likelihood ratio test comparing a multinomial logistic regression constraining the log-odds ratios from the <7 to ≥13 groups to be equal compared with an unconstrained model. The red dotted line shows nominal significance in heterogeneity (P < 0.05), and the red dashed line shows Bonferroni-corrected significance in heterogeneity. T1D, type 1 diabetes.