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. 2019 Oct 9;69(1):60–66. doi: 10.2337/db19-0554

Figure 4.

Figure 4

Quantitative results from whole-tissue sections analyzed for peri- and tele-islet AMY− cell clusters, insulin+/glucagon− islets, and insulin−/glucagon+ islets for control and Aab+ donors and donors with type 1 diabetes. A: The densities of both peri- and tele-islet AMY− clusters are shown. Donors with type 1 diabetes had a significantly lower density of peri-islet AMY− clusters than control donors without diabetes (P = 0.029). B: With expression as a percentage of total islets per section, donors with type 1 diabetes without residual ICIs (INS− T1D) had a smaller proportion of peri-islet AMY− cell clusters than control donors (4.3 ± 4.9% vs. 19.1 ± 15.1%), which trended toward significance (P = 0.084). C: A higher proportion of peri-islet AMY− clusters were found in association with insulin+/glucagon+ (Ins+/Gcg+) islets in donors with type 1 diabetes with residual ICIs (INS+T1D) than in association with insulin− (Ins−/Gcg+) islets in both INS+ and INS− donors with type 1 diabetes. A–C: Data points represent whole tissue sections for individual donors. Data are presented as mean ± SD and analyzed by one-way ANOVA with Tukey post hoc test for multiple comparisons.