Table 3.
Effect of type 2 diabetes–preventive strategies on 1-year change in CAD risk factors by study intervention
| CRF | PBO (n = 888) | MET (n = 880) | ILS (n = 890) | PILS vs. PBO | PMET vs. PBO |
|---|---|---|---|---|---|
| BMI, kg/m2 | −0.192 (−0.326, −0.057) | −0.911 (−1.047, −0.774) | −2.465 (−2.601, −2.330) | <0.001 | <0.001 |
| Waist circumference, cm | −0.843 (−1.268, −0.417) | −2.153 (−2.582, −1.725) | −6.479 (−6.905, −6.053) | <0.001 | <0.001 |
| Fasting glucose, mmol/L# | 0.001 (−0.006, 0.007) | −0.039 (−0.045, −0.032) | −0.052 (−0.058, −0.045) | <0.001 | <0.001 |
| LDLc, mmol/L | −0.060 (−0.097, −0.023) | −0.116 (−0.154, −0.078) | −0.161 (−0.199, −0.124) | <0.001 | 0.038 |
| HDL, mmol/L | −0.006 (−0.017, 0.005) | 0.021 (0.010, 0.032) | 0.038 (0.027, 0.049) | <0.001 | <0.001 |
| TG, mmol/L# | −0.060 (−0.084, −0.036) | −0.047 (−0.071, −0.023) | −0.169 (−0.193, −0.145) | <0.001 | 0.452 |
| SBP, mmHg | −0.728 (−1.538, 0.081) | −0.856 (−1.672, −0.040) | −3.003 (−3.814, −2.192) | <0.001 | 0.828 |
| DBP, mmHg | −0.955 (−1.483, −0.428) | −1.259 (−1.791, −0.728) | −3.550 (−4.078, −3.022) | <0.001 | 0.427 |
| CRP, mg/dL# | −0.020 (−0.069, 0.029) | −0.146 (−0.196, −0.097) | −0.396 (−0.445, −0.347) | <0.001 | <0.001 |
| tPA, ng/mL | −0.712 (−0.910, −0.515) | −2.049 (−2.249, −1.849) | −2.564 (−2.762, −2.367) | <0.001 | <0.001 |
| Fibrinogen, μmol/L | 0.084 (−0.039, 0.208) | −0.063 (−0.188, 0.061) | −0.298 (−0.421, −0.174) | <0.001 | 0.100 |
Values in this table represent adjusted mean (95% CI) change in CRF levels. P values from t tests comparing mean change in ILS or MET with PBO derived by general linear model adjusted for baseline risk factor, age at randomization, sex, and PCs ancestry markers.
#
For nonnormally distributed variables, we calculated the natural log year 1 value minus natural log baseline value and show mean (95% CI) change in CRF levels.