Table 3.
Association of BMI with postoperative complications*
| Entire Vanderbilt Cohort (n = 736,726) | |||||
|---|---|---|---|---|---|
| Phenotype | Underweight <18.5 kg/m2 OR (95% CI) |
Overweight 25.0-29.9 kg/m2 OR (95% CI) |
Obesity Class 1 30.0-34.9 kg/m2 OR (95% CI) |
Obesity Class 2 35.0-39.9 kg/m2 OR (95% CI) |
Obesity Class 3 ≥40.0 kg/m2 OR (95% CI) |
| Postoperative infection (n = 6,228) |
1.59 (1.42-1.76) † | 1.08 (1.01-1.15) | 1.18 (1.10-1.26) † | 1.57 (1.48-1.66) † | 2.25 (2.16-2.33) † |
| Incisional hernia (n = 3,580) |
0.92 (0.55-1.29) | 1.65 (1.54-1.76) † | 2.51 (2.40-2.62) † | 3.62 (3.51-3.75) † | 5.48 (5.36-5.60) † |
| Intestinal obstruction (n = 8,525) |
2.37 (2.26-2.47) † | 0.72 (0.67-0.78) † | 0.67 (0.61-0.74) † | 0.67 (0.58-0.76) † | 0.72 (0.62-0.82) † |
| Vanderbilt Surgical Cohort (n = 68,266) | |||||
| Postoperative infection (n = 2,749) |
1.66 (1.43-1.89) † | 0.92 (0.81-1.02) | 1.01 (0.89-1.13) | 1.36 (1.22-1.49) † | 2.13 (2.00-2.26) † |
| Incisional hernia (n = 3,120) |
0.67 (0.27-1.08) | 1.60 (1.49-1.72) † | 2.47 (2.35-2.59) † | 3.52 (3.39-3.65) † | 4.95 (4.81-5.08) † |
| Intestinal obstruction (n = 5,389) |
2.19 (2.03-2.33) † | 0.66 (0.59-0.73) † | 0.59 (0.50-0.67) † | 0.56 (0.44-0.67) † | 0.58 (0.45-0.71) † |
| Vanderbilt Exploratory Laparotomy Cohort (n = 2,410) | |||||
| Postoperative infection (n = 432) |
0.95 (0.36-1.55) | 1.25 (0.96-1.53) | 1.14 (0.81-1.47) | 1.39 (0.97-1.80) | 2.95 (2.55-3.34) † |
| Incisional hernia (n = 296) |
0.91 (0.08-1.73) | 1.79 (1.42-2.15) † | 2.00 (1.59-2.40) † | 4.47 (4.03-4.92) † | 4.63 (4.16-5.09) † |
| Intestinal obstruction (n = 688) |
1.11 (0.63-1.59) | 0.91 (0.66-1.16) | 0.62 (0.32-0.92) † | 1.14 (0.75-1.53) | 0.66 (0.23-1.10) |
| Vanderbilt Laparoscopy Cohort (n = 3,841) | |||||
| Postoperative infection (n = 174) |
1.06 (0.00-2.26) | 1.06 (0.60-1.51) | 1.17 (0.70-1.65) | 1.19 (0.65-1.73) | 1.56 (1.10-2.03) |
| Incisional hernia (n = 250) |
0.89 (0.00-2.35) | 1.35 (0.91-1.79) | 2.15 (1.71-2.59) † | 3.09 (2.63-3.55) † | 3.54 (3.10-3.98) † |
| Intestinal obstruction (n = 327) |
0.37 (0.80-2.26) | 0.16 (0.44-1.05) | 0.18 (0.21-0.91) † | 0.25 (0.00-0.90) † | 0.20 (0.15-0.95) |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); OR, odds ratio; CI, confidence interval
*
Reference odds ratio 1.0 represents normal median BMI. Logistic regressions adjusted for sex, age, and reported race.
†
Results significant to Bonferroni corrected p-value of p = 0.003 compared to individuals with normal range BMI.