Table 4.

Mendelian randomization genetic risk for obesity association with postoperative complications ^*

Entire eMERGE Cohort (n = 65,174)
Phenotype	OR per 1-SD BMI (95% CI)	p-value
Incisional hernia † (n = 1,620)	2.14 (1.83-2.45)	1.4 × 10−6
Postoperative infection † (n = 3,709)	1.64 (1.42-1.86)	3.1 ×10−6
Intestinal obstruction (n = 4,523)	1.05 (0.86-1.24)	0.595
eMERGE Surgical Cohort (n = 15,355)
Phenotype	OR per 1-SD BMI (95% CI)	p-value
Incisional hernia † (n =1,356)	1.82 (1.66-2.36)	9.4 × 10−5
Postoperative infection (n = 1,938)	2.01 (1.19-1.79)	0.009
Intestinal obstruction (n = 2,792)	0.97 (0.71-1.23)	0.801

Abbreviations: eMERGE, Electronic Medical Records and Genomics consortium; SE, standard error; OR, odds ratio

^*Logistic regression adjusted for site, sex, age, and first ten principal components. Odds ratio report per 1-SD (4.8 kg/m²) of BMI

^†Results significant to Bonferroni corrected p-value = 0.017.