Table 3 -.

Frequency of Query:

	Benefits	Pitfalls
Clinical Visits	Can be integrated into existing clinic workflow Patients physically present to complete PRO and to be given reminders	PRO query at defined clinical encounters miss symptom changes between visits Symptoms already assessed by clinician during clinical visit
Set Timepoints (Paper)	Obtain PRO at set timepoints not associated with clinical visits	Higher patient burden to complete and return Higher administrative staff burden to reliably obtain and give to clinician Delayed clinician actionability due to delayed receipt
Push Notification (Electronic, Smartphone)	Obtain PRO at set timepoints not associated with clinical visits Higher likelihood for completion with technological facile patients Frequent symptom monitoring may result in early detection of clinical changes	Too frequent query will result in survey fatigue Higher clinical staff burden to monitor PRO with potential of data overload Unclear effects on clinical liability
Continuous Communication	Continuous patient data capture using wearable devices Just-in-time symptom monitoring may result in early detection of clinical changes	Need for robust infrastructure for data capture, monitoring, and management Higher clinical staff burden Patient compliance with wearable devices Unclear effects of clinical liability