Table 1.
Genes and associated drugs included in CPIC guidelines as of July 2019
| Gene | Drugs | References |
|---|---|---|
| CACNA1S | volatile anesthetic agents, succinylcholine | (13) |
| CFTR | ivacaftor | (14) |
| CYP2B6 | efavirenz | (15) |
| CYP2C19 | clopidogrel, voriconazole, SSRIs, TCAs, PPIsa | (16–19) |
| CYP2C9 | phenytoin, warfarin, NSAIDsa | (20, 21) |
| CYP2D6 | atomoxetine, codeine, ondansetron, tramadol, tropisetron, tamoxifen, SSRIs, TCAs | (17, 22–25) |
| CYP3A5 | tacrolimus | (26) |
| CYP4F2 | warfarin | (21) |
| DPYD | capecitabine, fluorouracil | (27) |
| G6PD | rasburicase | (28) |
| HLA-A | carbamazepine | (20, 29) |
| HLA-B | carbamazepine, oxcarbazepine, abacavir, allopurinol, phenytoin | (29–31) |
| IFNL3 | peginterferon alfa | (32) |
| mtRNR1 | aminoglycosides | underway |
| NUDT15 | azathioprine, mercaptopurine, thioguanine | (18) |
| RYR1 | volatile anesthetic agents, succinylcholine | (13) |
| SLCO1B1 | simvastatin | (33) |
| TPMT | azathioprine, mercaptopurine, thioguanine | (18) |
| UGT1A1 | atazanavir | (34) |
| VKORC1 | warfarin | (21) |
SSRI, selective serotonin reuptake inhibitors; TCA, tricyclic antidepressants; PPIs, proton pump inhibitors; NSAIDs, non-steroidal anti-inflammatory drugs
a
Guideline underway