Table 2A:
Patient characteristics for the ASCA analysis
| Non-alcoholic Controls |
Alcohol Use Disorder |
Alcoholic Hepatitis |
p value | |
|---|---|---|---|---|
| Clinical parameter | ||||
| Total n | 23 | 40 | 163 | |
| Age (years), n=224 | 46 (26-76) | 43 (27-63) | 49 (26-75) | 0.022* |
| Body Mass Index (BMI), kg/m², n=198 | 22.9 (18.8-42.3) | 23.6 (17.9-35.5) | 26.8 (16.3-44.6) | <0.001* |
| Male gender, %, n=226 | 87 | 82.5 | 66.5 | 0.033* |
| Laboratory parameter | ||||
| ASCA (IU/ml), n=226 | 10.7 (5.9-25.5) | 13.0 (4.5-37.0) | 26.0 (5.2-133.9) | <0.001* |
| Albumin (g/dl), n=182 | 4.5 (2.2-5.2) | 2.5 (0.2-4.2) | <0.001 | |
| Alkaline phosphatase (U/l), n=184 | 68 (33-225) | 170 (21-1153) | <0.001 | |
| ALT (IU/l), n=197 | 37.5 (9-184) | 44 (15-404) | 0.568 | |
| AST (IU/l), n=197 | 48 (15-283) | 130 (34-1858) | <0.001 | |
| Total bilirubin (mg/dl), n=194 | 0.5 (0.2-1.5) | 13.7 (2.5-51.8) | <0.001 | |
| GGT (IU/l), n=121 | 95 (15-1131) | 257 (33-3632) | <0.001 | |
| Platelet counts (x10 9/l), n=194 | 220 (21-434) | 122 (12-447) | <0.001 | |
| Prothrombin time, s, n=138 | 22.1 (9-141) | |||
| Creatinine (mg/dl), n=202 | 0.8 (0.2-1.3) | 0.8 (0.2-8.1) | 0.051 | |
| Sodium (mEq/l), n=158 | 134 (106-208) | |||
| INR, n=187 | 0.94 (0.8-1.1) | 1.8 (0.8-7.6) | <0.001 | |
| Non-invasive fibrosis diagnostic and ultrasound | ||||
| Steatosis in ultrasound, n (%), n=32 | 23 (72) | |||
| FIB-4, n=193 | 1.6 (0.3-21.4) | 7.6 (0.7-73.4) | <0.001 | |
| <1.45 (F0-F1), n (%) | 18 (47.4) | 3 (1.9) | <0.001 | |
| 1.45-3.25 (intermediate), n (%) | 14 (36.8) | 11 (7.1) | ||
| >3.25 (F3-F4), n (%) | 6 (15.8) | 141 (91) |
Values are presented as median and range in brackets. The number of patients for which the respective data was available is indicated in the first column. In blank cells, patients from the respective group were not counted to missing numbers. One-Way ANOVA with Tukeýs post-hoc test.
Post hoc p values: Age: AUD vs. AH p=0.0226; Ctrl vs. AH p=0.419; Ctrl vs. AUD p=0.750. BMI: AUD vs. AH p= <0.001; Ctrl vs. AH p=0.023; Ctrl vs. AUD p=0.954. Gender male: AUD vs. AH p=0.058; Ctrl vs. AH p=0.062; Ctrl vs. AUD p=0.642. ASCA: AUD vs. AH p=<0.001; Ctrl vs. AH p=<0.001; Ctrl vs. AUD p= 0.863. ASCA: AUD vs. AH =<0.001; Ctrl vs. AH =<0.001; Ctrl vs. AUD p=0.864. Bold font indicates significance (p value <0.05). ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; AUD, alcohol use disorder; AH, alcoholic hepatitis; Ctrl, non-alcoholic controls; INR, international normalized ratio; FIB-4, fibrosis-4 index; GGT, gamma-glutamyl-transferase; BMI, body mass index.