Table 3:

High ASCA levels are associated with increased 90- and 180-Day mortality in patients with alcoholic hepatitis

Dependent: 90 Day Mortality		Survival, % (95% CI)	HR (univariable), (95% CI, p value)	HR (multivariable), (95% CI, p value*)	HR (multivariable), (95% CI, p value**)
ASCA	<34 IU/ml	80.0 (72.4-88.2)	-
	≥34 IU/ml	59.1 (45.5-76.8)	2.22 (1.15-4.30, p=0.017)	3.27 (1.21-8.86, p=0.020)	3.13 (1.11-8.82, p=0.031)
MELD			1.11 (1.07-1.16, p<0.001)	1.13 (1.07-1.19, p<0.001)	1.13 (1.07-1.19, p<0.001)
Dependent: 180 Day Mortality
ASCA	<34 IU/ml	63.4 (48.4-83.1)
	≥34 IU/ml	29.9 (13.9-64.6)	2.32 (1.28-4.21, p=0.006)	3.48 (1.50-8.10, p=0.004)	3.07 (1.30-7.28, p=0.011)
MELD			1.10 (1.06-1.15, p<0.001)	1.13 (1.08-1.18, p<0.001)	1.12 (1.07-1.17, p<0.001)

^*p value adjusted for MELD score, infection, antibiotics, steroids, pentoxifylline.

^**p value adjusted for MELD score, infection, antibiotics, steroids, pentoxifylline and LPS-BP. Likelihood ratio test. Bold font indicates significance (p value <0.05). HR, hazard ratio; CI, confidence interval; ASCA, anti-Saccharomyces cerevisiae antibodies; LPS-BP, lipopolysaccharide binding protein; MELD, Model for End-stage Liver Disease.