Table 2.
Genotype distribution and allele frequencies of MCP-1 polymorphisms in healthy controls and patients with Schizophrenia.
| Genotype | Healthy controls n = 200 (%) | Patients n = 200 (%) | OR (95% CI) | P value | AIC |
|---|---|---|---|---|---|
| MCP-1 -2518A/G (rs1024611) | |||||
| Genotypes | |||||
| AA | 124 (62%) | 166 (83%) | |||
| AG | 69 (34.5%) | 33 (16.5%) | 0.35 (0.22–0.57) | 0.000015∗ | |
| GG | 7 (3.5%) | 1 (0.5%) | 0.10 (0.004–0.7) | 0.015∗ | 536.4 |
| Dominant (AA vs AG + GG) | 0.33 (0.20–0.53) | 0.0000023∗ | 536∗ | ||
| Recessive (AA + AG vs GG) | 0.13 (0.006–0.9) | 0.067 | 553.4 | ||
| HWEa | 0.48 | 0.22 | |||
| Alleles | |||||
| A | 317 (79.25%) | 365 (91.25%) | |||
| G | 83 (20.75%) | 35 (8.75%) | 0.36 (0.23–0.55) | 0.000001∗ | |
| MCP-1 -362 G/C (rs2857656) | |||||
| Genotypes | |||||
| GG | 67 (33.5%) | 46 (23%) | |||
| GC | 92 (46%) | 88 (44%) | 1.3 (0.86–2.24) | 0.17 | |
| CC | 41 (20.5%) | 66 (33%) | 2.33 (1.36–4.03) | 0.001∗ | 552.4 |
| Dominant (GG vs GC + CC) | 1.68 (1.08–2.63) | 0.02∗ | 554.8 | ||
| Recessive (GG + GC vs CC) | 1.9 (1.21–3.01) | 0.004∗ | 552∗ | ||
| HWEa | 0.82 | 2.46 | |||
| Alleles | |||||
| G | 226 (56.5%) | 180 (45%) | |||
| C | 174 (43.5%) | 220 (55%) | 1.58 (1.2–2.09) | 0.001∗ | |
| MCP-1 int1del554-567 (rs3917887) | |||||
| Genotypes | |||||
| Ins/Ins | 136 (68%) | 154 (77%) | |||
| Ins/Del | 59 (29.5%) | 41 (20.5%) | 0.61 (0.38–0.97) | 0.03∗ | |
| Del/Del | 5 (2.5%) | 5 (2.5%) | 0.88 (0.23–3.3) | 0.8 | 553.1 |
| Dominant (Ins/Ins vs Ins/Del + Del/Del) | — | — | 0.63 (0.4–0.98) | 0.04∗ | 551.4∗ |
| Recessive (Ins/Ins + Ins/Del vs Del/Del) | — | — | 1 (0.26–3.77) | >0.99 | 555.7 |
| HWEa | 0.22 | 1.23 | |||
| Alleles | |||||
| Ins | 331 (82.75%) | 349 (87.25%) | |||
| Del | 69 (17.25%) | 51 (12.75%) | 0.7 (0.47–1.03) | 0.075 | |
OR: odds ratio; CI: confidence interval; HC: healthy controls; ∗P < 0.05; HWE: Hardy–Weinberg equilibrium; aChi-square value AIC (Akaike information criterion) provides a means for model selection.