Table 2.
Clinicopathological features of MSI cancers.
| Characteristics | Defect MMR | Intact MMR | P value |
|---|---|---|---|
| Age | |||
| Mean | 51.5 (±14.18) | 55.0 (±15.45) | 0.1 |
| ≤57 | 26 (70.3%) | 144 (49.1%) | 0.01 |
| ≥57 | 11 (29.7%) | 149 (50.9%) | |
| Gender | |||
| Female | 10 (27.0%) | 146 (49.8%) | 0.007 |
| Male | 27 (73.0%) | 147 (50.2%) | |
| Tumor site | |||
| Right colon | 23 (62.2%) | 53 (18.1%) | 0.000 |
| Left colon | 14 (37.8%) | 240 (81.9%) | |
| Histologic subtype | |||
| Adenocarcinoma | 30 (81.8%) | 248 (84.6%) | |
| Mucinous adenocarcinoma | 6 (16.2%) | 23 (7.8%) | 0.1 |
| Others | 1 (2.7%) | 22 (7.5%) | |
| Histologic grade | |||
| Well | 15 (40.5%) | 208 (71.5%) | 0.000 |
| Poor | 22 (59.5%) | 83 (28.5%) | |
| Vascular invasion | |||
| Yes | 7 (18.9%) | 32 (10.9%) | 0.1 |
| No | 30 (81.1%) | 261 (89.1%) | |
| Perineural invasion | |||
| Yes | 2 (5.7%) | 25 (9.5%) | 0.3 |
| No | 33 (94.3%) | 239 (90.5%) | |
| Family history of cancer | |||
| Yes | 3 (8.1%) | 9 (3.1%) | 0.1 |
| No | 34 (91.9%) | 284 (96.9%) | |
| Tumor stage (T) | |||
| T1 | 0 (0.0%) | 4 (1.3%) | 0.5 |
| T2 | 5 (13.5%) | 47 (16.2%) | |
| T3 | 25 (67.6%) | 173 (59.5%) | |
| T4 | 7 (18.9%) | 67 (23.0%) | |
| Distant metastases (M) | |||
| M0 | 36 (97.3%) | 222 (76.8%) | 0.001 |
| M1 | 1 (2.7%) | 67 (23.2%) | |
| Disease stages | |||
| I-II | 28 (75.7%) | 160 (54.6%) | 0.01 |
| III-IV | 9 (24.3%) | 133 (45.4%) | |
| RAS mutation | |||
| Presence | 6 (15.8%) | 32 (84.2%) | 0.09 |
| Absence | 12 (15.4%) | 66 (84.6%) |
MMR: mismatch repair; SD: standard deviation.