Table 2.
Effect of Manilkara zapota extracts: chloroform (Mz.CHCl3), aqueous (Mz.Aq), and atropine on charcoal meal transit time in rats.
| Doses (mg/kg, p.o.) | Mean length of intestine (cm) | Distance moved by charcoal (cm) | % intestinal transient | % inhibition |
|---|---|---|---|---|
| Saline (10 mL/kg) | 92.6 ± 1.6 | 90 ± 1.3 | 97.1 | — |
| Mz.CHCl3 (50 mg/kg) | 87.4 ± 1.3 | 76.6 ± 1.9∗∗∗ | 87.64 | 9.74 |
| Mz.CHCl3 (100 mg/kg) | 90.8 ± 0.8 | 70.6 ± 0.8∗ | 77.75 | 19.92 |
| Mz.CHCl3 (300 mg/kg) | 84.4 ± 0.5 | 59.8 ± 0.3∗∗∗ | 70.85 | 27.03 |
| Mz.Aq (50 mg/kg) | 73.6 ± 0.9 | 86.6 ± 0.2 | 84.98 | 12.48 |
| Mz.Aq (100 mg/kg) | 74.2 ± 0.5 | 57 ± 0.7∗ | 76.81 | 20.89 |
| Mz.Aq (300 mg/kg) | 77 ± 0.7 | 55.4 ± 0.9∗∗ | 71.94 | 25.91 |
| Atropine (0.1 mg/kg, i.p.) | 90.8 ± 0.9 | 16.4 ± 0.6∗∗∗ | 18.06 | 81.40 |
∗ p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 compared to control saline group. One-way analysis of variance followed by Tukey's post hoc test, n = 5.