Table 5.
Effect of crude extract of C. aurantium on urinary sodium and potassium levels in rats treated with cisplatin.
| Days of observation | |||||
|---|---|---|---|---|---|
| Parameter | Groups | 0th day | 7th day | 14th day | 21st day |
| Urinary sodium (mEq/24 h) | Control | 172 ± 4.0 | 180 ± 9.2 | 190 ± 7.3 | 170 ± 8.4 |
| Cisplatin | 169 ± 4.5 | 300 ± 11∗∗∗ | 303 ± 11∗∗∗ | 347 ± 17∗∗∗ | |
| Cisplatin + C. aurantium (200 mg/kg) | 172 ± 8.0 | 261 ± 8.0∗∗∗ | 267 ± 7.8∗∗∗ | 296 ± 11∗∗∗ | |
| Cisplatin + C. aurantium (400 mg/kg) | 164 ± 6.2∗∗∗ | 218 ± 8.3∗∗∗ | 228 ± 8.7∗∗∗ | 247 ± 7.8∗∗∗ | |
| Urinary potassium (mEq/24 h) | Control | 3.8 ± 0.35 | 3.0 ± 0.25 | 3.3 ± 0.35 | 3.5 ± 0.19 |
| Cisplatin | 3.4 ± 0.36∗∗∗ | 4.3 ± 0.19∗∗∗ | 4.7 ± 0.29∗∗∗ | 5.1 ± 0.34∗∗∗ | |
| Cisplatin + C. aurantium (200 mg/kg) | 3.5 ± 0.26∗∗∗ | 3.1 ± 0.20 | 3.4 ± 0.24 | 3.6 ± 0.17 | |
| Cisplatin + C. aurantium (400 mg/kg) | 3.3 ± 0.51∗∗∗ | 1.6 ± 0.20∗∗∗ | 2.2 ± 0.27∗∗∗ | 2.8 ± 0.32∗∗∗ | |
Statistical analysis was done through one-way analysis of variance (ANOVA) trailed by Bonferroni post hoc test for all groups in respective days. The results are considered significant (∗) if p < 0.005. ∗∗∗p < 0.05. Results were compared in a column with the respective control values.