Figure 11.

Effects of I1PP1 overexpression and KN93 on mitochondrial membrane potential in cardiomyocytes after H/R injury. After infection of the I1PP1 recombinant adenovirus, the cardiomyocytes with or without CaMKII inhibitor KN93 incubation for 1 h were subjected to hypoxia for 4 h followed by 12 h reoxygenation. Mitochondrial membrane potential (Δψm) was measured by JC-1 staining and quantified using ImageJ analysis software. Bar = 25 μm. Plots represent the mean ± SEM; n = 6. Statistical significance: ^∗∗P < 0.01 compared with vector+H/R.