(a).

Parameters	n = 511		eIF3A expression		p value	eIF3B expression		p value	eIF3C expression		p value	eIF3D expression		p value
			High (n = 254)	Low (n = 257)		High (n = 258)	Low (n = 253)		High (n = 256)	Low (n = 255)		High (n = 258)	Low (n = 253)
Age (years, mean ± SEM)	<65	219	105	114	0.5870	126	93	0.0050∗	103	116	0.3195	108	111	0.7856
	≥65	273	138	135		122	151		141	132		139	134
	No data	19
Gender	Females	277	120	157	0.0019∗	132	145	0.1830	137	140	0.7902	139	138	>0.9999
	Males	234	134	100		126	108		119	115		117	117
Pathological stage	I/II	395	189	206	0.1285	189	206	0.0168∗	188	207	0.0388∗	184	206	0.0046∗
	III/IV	108	61	47		66	42		64	44		68	40
	No data	8
Residual tumour	R0	342	160	182	0.6294	173	169	>0.9999	169	173	>0.9999	163	176	0.0257∗
	R1/R2	17	9	8		9	8		8	9		13	4
	RX/no data	152
Smoking history	1	75	29	46	0.0336∗	32	43	0.1679	34	41	0.3807	41	34	0.3807
	2/3/4/5	422	220	202		219	203		217	205		205	217
	No data	14
Radiation therapy	No	396	204	192	0.1616	194	202	0.0483∗	196	200	>0.9999	188	208	0.1232
	Yes	58	24	34		37	21		29	29		34	24
	No data	57
Targeted molecular therapy	No	302	146	156	0.2308	143	159	0.0361∗	154	148	0.4245	138	164	0.0357∗
	Yes	150	82	68		87	63		70	80		85	65
	No data	59
Mutations in KRAS/EGFR/ALK	No	132	68	64	0.8935	65	67	0.1790	65	67	0.4230	78	54	0.3455
	Yes	95	50	45		38	57		52	43		50	45
	No data	284