Table 6.
Alteration of selected mitochondrial proteins in fructose-fed rats by proteomic analysis. Values are expressed as fold change and p value.
| Protein names | Gene names | Fold change | p value |
|---|---|---|---|
| Pyruvate dehydrogenase complex | |||
| Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (mitochondrial) | Dlat | -3.47 | 0.022 |
| Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex | Dbt | -9.53 | 0.039 |
| Electron transport chain | |||
| ETF-ubiquinone oxidoreductase (mitochondrial) | Etfdh | 3.13 | 0.004 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | Ndufa2 | 2.06 | 0.047 |
| NADH-ubiquinone oxidoreductase chain 4 | Mt-Nd4 | 1.59 | 0.007 |
| Cytochrome c, testis-specific | Cyct | 1.56 | 0.011 |
| Cytochrome b-c1 complex subunit Rieske (mitochondrial) | Uqcrfs1 | -1.95 | 0.001 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10 (mitochondrial) | Ndufa10 | -3.15 | 0.038 |
| Amino acid metabolism | |||
| 3-Hydroxyisobutyryl-CoA hydrolase (mitochondrial) | Hibch | 5.44 | 0.042 |
| Isovaleryl-CoA dehydrogenase (mitochondrial) | Ivd | -1.90 | 0.004 |
| Methylcrotonoyl-CoA carboxylase beta chain (mitochondrial) | Mccc2 | -2.18 | 0.046 |
| Transport function | |||
| ADP/ATP translocase 1 | Slc25a4 | 2.47 | 0.005 |
| Voltage-dependent anion-selective channel protein 3 | Vdac3 | 2.17 | 0.018 |
| MICOS complex subunit Mic60 | Immt | 1.58 | 0.003 |
| Beta oxidation | |||
| Enoyl CoA hydratase domain-containing 2 | Echdc2 | 1.50 | 0.018 |
| Electron transfer flavoprotein subunit alpha (mitochondrial) | Etfa | -1.94 | 0.001 |
| Other | |||
| Malic enzyme | Me3 | 4.27 | 0.022 |
| Citrate synthase | Cs | 3.14 | ≤0.001 |
| Enoyl-[acyl-carrier-protein] reductase (mitochondrial) | Mecr | -1.61 | 0.029 |
| Prohibitin-2 | Phb2 | -1.65 | 0.001 |