Fig. 4.

Levels of synaptic proteins in the infarct core and peri-infarct area 14 days after photothrombosis (PT) or in the homotypic area in sham operated mice have been analyzed after treatment with Vehicle (Vh; n = 6 for PT and n = 3 for sham) or T₃ 50 μg/kg (n = 6 for PT and n = 3 for sham). There are no significant differences between levels of postsynaptic density protein 95 (PSD95), synaptophysin, glutamate receptor 1 (GluR1) and NMDA receptor 1 in the infarct core and peri-infarct in T₃-treated mice compared with Vh. Levels of AMPA receptor subunit GluR2 and synaptotagmin 1&2 are increased in the infarct core and peri-infarct in T₃-treated mice compared with Vh. Synaptotagmins are vesicle-associated synaptic proteins involved in neurotransmitter release. For uncropped images of western blots see Additional file 1: Figure S6. No differences were observed in sham operated mice. Results are displayed as means ± SEM. Statistical analysis was performed with two-tailed unpaired Student’s t test