Table 1.
Basal metabolic characteristics of Wistar (n = 8) and HHTg rats (n = 8) observed over the course of aging at 3, 12, and 20 months of age.
| Wistar | HHTg | P 1 value | P 2 value | |||||
|---|---|---|---|---|---|---|---|---|
| 3 m | 12 m | 20 m | 3 m | 12 m | 20 m | |||
| Body weight | 407 ± 5 | 635 ± 28 | 663 ± 21 | 304 ± 5 | 478 ± 14 | 566 ± 12 | ∗∗∗ | n.s. |
| Adiposity index | 1.090 ± 0.057 | 1.457 ± 0.151 | 1.316 ± 0.195 | 1.161 ± 0.044 | 2.531 ± 0.043 | 2.534 ± 0.070 | ∗∗∗ | ∗∗∗ |
| Perirenal adipose tissue | 0.971 ± 0.061 | 1.760 ± 0.067 | 1.946 ± 0.202 | 1.386 ± 0.308 | 3.110 ± 0.107 | 2.437 ± 0.111 | ∗∗∗ | ∗ |
| Nonfasting glucose Insulin |
7.2 ± 0.3 0.198 ± 0.047 |
6.6 ± 0.1 0.213 ± 0.023 |
6.4 ± 0.6 0.278 ± 0.045 |
7.8 ± 0.2 0.307 ± 0.053 |
8.2 ± 0.3 0.286 ± 0.046 |
7.6 ± 0.7 0.353 ± 0.081 |
∗∗
∗∗ |
∗
n.s. |
| AUC0-120 | 660 ± 43 | 705 ± 16 | 679 ± 26 | 737 ± 26 | 1036 ± 35 | 1011 ± 55 | ∗∗ | ∗ |
| Serum triglycerides | 1.55 ± 0.14 | 1.84 ± 0.18 | 2.07 ± 0.51 | 5.45 ± 0.45 | 5.33 ± 0.72 | 9.82 ± 0.79 | ∗∗∗ | ∗∗∗ |
| Serum cholesterol | 1.74 ± 0.11 | 2.33 ± 0.16 | 4.12 ± 0.72 | 1.52 ± 0.05 | 1.69 ± 0.09 | 2.71 ± 0.26 | ∗∗ | n.s. |
| HDL-C | 1.35 ± 0.13 | 1.57 ± 0.11 | 2.26 ± 0.27 | 0.56 ± 0.05 | 0.66 ± 0.03 | 0.45 ± 0.06 | ∗∗∗ | ∗∗∗ |
| NEFA Hepatic triglycerides |
0.209 ± 0.021 7.25 ± 0.45 |
0.360 ± 0.025 9.99 ± 1.04 |
0.334 ± 0.027 5.08 ± 0.40 |
0.401 ± 0.037 11.03 ± 0.77 |
0.661 ± 0.053 20.73 ± 1.23 |
0.473 ± 0.072 15.96 ± 1.57 |
∗∗∗
∗∗∗ |
∗
∗∗ |
Values are given as mean ± SEM, n = 8 for each group; ∗ denotes P < 0.05, ∗∗denotes P < 0.01, and ∗∗∗ denotes P < 0.001. Body weight (g), adiposity index (mg/g), perirenal adipose tissue (mg/g), glucose, triglycerides, cholesterol, AUC0-120 (mmol/l), HDL-C and NEFA (mmol/l), hepatic triglycerides (μmol/g), insulin (nmol/l). P1 value: probability reflecting the effect of the strain. The analysis was performed using BMDP statistical software by two-way ANOVA and by the Bonferroni post hoc test for multiple comparisons. P2 value: probability reflecting the combined effect of the strain and ageing. The analysis was performed using BMDP statistical software by two-way ANOVA and by the Bonferroni post hoc test for multiple comparisons.